Key result
Intravascular laser speckle imaging successfully measures arterial wall viscoelasticity and distinguishes normal from stented sites.
A prototype intravascular laser speckle imaging catheter is feasible for in vivo evaluation of arterial wall mechanical properties, potentially aiding in atherosclerotic plaque assessment.
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Prototype feasible in animals; leaves open translation to human plaque assessment.
Hajjarian et al. (2011) studied Atherosclerotic plaques. Intravascular laser speckle imaging (LSI) catheter vs. Free-space bulk optics system (ex vivo) was evaluated on Feasibility of conducting LSI in vivo and correlation of plaque time constants. An intravascular laser speckle imaging catheter successfully measured arterial wall viscoelasticity, correlating well with bulk optics ex vivo and distinguishing normal from stented sites in vivo.
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