What question did this study set out to answer?

To evaluate whether prior intake of the artificial sweeteners saccharin and cyclamate increases the risk of urinary bladder cancer in humans.

July 28, 1978JAMA

Saccharin, Cyclamate, and Human Bladder Cancer

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To evaluate whether prior intake of the artificial sweeteners saccharin and cyclamate increases the risk of urinary bladder cancer in humans.
Conducted a case-control study comparing 519 patients with histopathologically confirmed bladder cancer to 519 matched controls in metropolitan Baltimore.
Assessed prior intake frequency, quantity, and duration of saccharin and cyclamate while adjusting for smoking, occupation, age, diabetes mellitus, and other potential confounders.
Prior intake of saccharin and cyclamate did not differ significantly between bladder cancer cases and controls in frequency, quantity, or duration.
Relative risk of bladder cancer failed to increase with escalating exposure to artificial sweeteners after simultaneous adjustment for confounding variables.

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Implication

Case-control study finds no association between artificial sweetener intake and bladder cancer in adults, suggesting moderate dietary exposure does not elevate risk.

Cite This Study

Irving I. Kessler (1978) studied this question.

synapsesocial.com/papers/6aa67c0bb3a9aaf5308e4732 https://doi.org/10.1001/jama.1978.03290040027017

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Implication

Case-control study finds no association between artificial sweetener intake and bladder cancer in adults, suggesting moderate dietary exposure does not elevate risk.

Saccharin, Cyclamate, and Human Bladder Cancer

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Saccharin, Cyclamate, and Human Bladder Cancer

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Implication

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