Key result
IV synthetic lipid vesicles deposit ~25% of enclosed 99mTcO4- radioactivity in the mouse liver.
Population
C(3)H mice
Comparison
Intravenous injection of synthetic lipid… vs Free (99m)TcO(4) (-) or (99m)Tc sulfur colloid
Design
Preclinical
Follow-up
Up to 46 minutes
Authors
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Lipid vesicle stability in mice supports carrier potential; extends preclinical data but leaves open human translation.
Synthetic lipid vesicles can remain intact in circulation and their distribution can be modified by altering their composition, suggesting potential as carriers for diagnostic or therapeutic agents.
McDougall et al. (1974) studied this question. Synthetic lipid vesicles enclosing (99m)TcO(4) (-) vs. Free (99m)TcO(4) (-) or (99m)Tc sulfur colloid was evaluated on Distribution of radioactivity in the liver and circulation. Intravenously injected synthetic lipid vesicles enclosing (99m)TcO(4) (-) resulted in about 25% of radioactivity in the liver and 10-20% in the circulation at 5 and 30 minutes in mice.
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