Why the study?
Does an intra-arterial vasodilating cocktail reduce the incidence and severity of radial artery spasm in patients undergoing coronary procedures via the radial artery?
Population
100 patients undergoing coronary procedures via the radial artery
Comparison
Intra-arterial cocktail prior to sheath insertion vs No vasodilating drug
Design
Cohort
Follow-up
At the end of the procedure (sheath removal)
Key result
An intra-arterial vasodilating cocktail of verapamil and nitroglycerine significantly reduced the incidence of pain during sheath removal compared to no vasodilating drug (14% vs 34%; P=0.019).
Authors
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May reduce sheath removal pain in transradial access; leaves open whether vasodilator cocktails prevent radial spasm in randomized trials.
RCT (n=100)
Does an intra-arterial vasodilating cocktail reduce the incidence and severity of radial artery spasm in patients undergoing coronary procedures via the radial artery?
Absolute Event Rate: 14% vs 34%
p-value: p=0.019
Administration of an intra-arterial cocktail of verapamil and nitroglycerine prior to sheath insertion significantly reduces the occurrence and severity of radial artery spasm during transradial coronary procedures.
Kiemeneij et al. (2003) conducted an RCT in Radial artery spasm during coronary procedures (n=100). Intra-arterial vasodilating cocktail (verapamil and nitroglycerine) vs. No vasodilating drug was evaluated on Pain (pain score of III-V) during automatic sheath removal (p=0.019). An intra-arterial vasodilating cocktail of verapamil and nitroglycerine significantly reduced the incidence of pain during sheath removal compared to no vasodilating drug (14% vs 34%; P=0.019).
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