Key result
Fine needle aspiration with cell block and immunohistochemistry differentiates secondary angiosarcoma from carcinoma recurrence.
Case Report (n=1)
Fine needle aspiration with ancillary techniques can successfully diagnose secondary angiosarcoma of the breast, differentiating it from carcinoma recurrence.
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May aid diagnosis of secondary breast angiosarcoma; leaves open broader applicability pending validation studies.
BACKGROUND: Angiosarcoma is a rare malignant soft tissue tumor occurring at various sites as either a primary or secondary event. Primary angiosarcoma of the breast is an unusual tumor, counting for 1 in 1700-2,000 primary malignant tumors of this organ. An increasing number of secondary angiosarcomas involving skin and breast. CASE: Angiosarcoma arose 6 years after breast-conserving therapy for invasive carcinoma in a 69-year-old woman. Fine needle aspiration of several small, reddish, intradermal nodules over the treated area revealed malignant cells with an endothelial immunophenotype in the cel block, yielding the diagnosis of angiosarcoma, subsequently confired in a mastectomy speciman. CONCLUSION: Fine needle aspiration, supported by ancillary techniques, such as cell block and immunohistochemistry, allows the cytologic diagnosis of an angiosarcoma and differentiates it from a carcinoma recurrence.
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Pfeiffer et al. (2006) conducted a case report in Secondary angiosarcoma after breast-conserving therapy (n=1). Fine needle aspiration biopsy with cell block and immunohistochemistry was evaluated on Cytologic diagnosis of angiosarcoma. Fine needle aspiration supported by cell block and immunohistochemistry successfully diagnosed secondary angiosarcoma and differentiated it from carcinoma recurrence in a 69-year-old woman.
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