Key result
MIII DeltaK yields ~2-fold higher actin-activated ATPase rate and tighter actin affinity versus MIII.
Effect estimate: 2-fold higher
The absence of the kinase domain in myosin IIIA enhances its motor activity and actin affinity, suggesting the kinase domain regulates its localization and function in sensory cells.
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Hypothesis-generating for myosin IIIA regulation; leaves open in vivo relevance to sensory cell function.
Dosé et al. (2008) studied this question. Myosin IIIA without the kinase domain (MIII DeltaK) vs. Myosin IIIA containing the kinase domain (MIII) was evaluated on Maximum actin-activated ATPase rate (2-fold higher). Myosin IIIA without the kinase domain (MIII DeltaK) demonstrated a 2-fold higher maximum actin-activated ATPase rate (kcat = 1.5 +/- 0.1 s-1) and a 5-fold tighter actin affinity compared to MIII.
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