Key result
SPECT reverse redistribution in AMI is linked to ~56% lower post-exercise LV contraction versus normal regions.
Why the study?
Does the reverse redistribution phenomenon on rest 99mTc-tetrofosmin SPECT indicate impaired left ventricular contraction in patients with acute myocardial infarction?
Population
25 patients evaluated 3 weeks after the onset of acute myocardial infarction
Comparison
Rest 99mTc-tetrofosmin myocardial SPECT and… vs Intra-patient comparison between myocardial…
Design
Cross-sectional
Authors
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Should not change practice in AMI; leaves open whether reverse redistribution predicts outcomes or guides therapy.
Observational (n=25)
No
Does the reverse redistribution phenomenon on rest 99mTc-tetrofosmin SPECT indicate impaired left ventricular contraction in patients with acute myocardial infarction?
Absolute Event Rate: 10.4% vs 23.5%
p-value: p=<0.001
The reverse redistribution phenomenon on rest 99mTc-tetrofosmin SPECT identifies myocardial regions with severely impaired left ventricular contraction in patients with recent acute myocardial infarction.
Kurokawa et al. (2003) conducted an observational in Acute myocardial infarction (n=25). Reverse redistribution phenomenon on 99mTc-tetrofosmin SPECT vs. Normal myocardial regions was evaluated on Percent count increase (%CI) during myocardial contraction after exercise (p=<0.001). In patients with acute myocardial infarction, myocardial regions showing the reverse redistribution phenomenon on 99mTc-tetrofosmin SPECT exhibited severely impaired left ventricular wall contraction after exercise compared to normal regions (10.4% vs 23.5%, p<0.001).