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A novel optically active 2-(oxazolinyl)pyridine ligand (Spymox) having a spiro binaphthyl backbone was synthesized from an α,α-disubstituted α-amino acid (H-Bin-OH), and successfully used in palladium-catalyzed asymmetric allylic alkylations to afford the corresponding alkylated products with 99% ee.
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Shibatomi et al. (2009) studied this question.
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