Key result
The SNP rs391745 C-allele near HERV-Fc1 is linked to ~54% higher multiple sclerosis risk.
Why the study?
Are genetic polymorphisms in TRIM5 and near the endogenous retrovirus HERV-Fc1 associated with multiple sclerosis?
Population
1,155 patients with verified multiple sclerosis and 2,096 controls across 4 cohorts of ethnically Danish…
Comparison
Polymorphisms near viral restriction genes or… vs Controls without multiple sclerosis
Design
Case-control
Authors
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Does not alter MS clinical practice; hypothesis-generating for HERV-Fc1 and needs prospective validation.
Case-Control (n=3,251)
Are genetic polymorphisms in TRIM5 and near the endogenous retrovirus HERV-Fc1 associated with multiple sclerosis?
Odds Ratio: 1.54 (95% CI 1.27–1.87)
Absolute Event Rate: 20% vs 14%
p-value: p=1.3*10^-5
Genetic polymorphisms in TRIM5 and near the endogenous retrovirus HERV-Fc1 are associated with multiple sclerosis, supporting a potential retroviral role in the disease etiology.
Nexø et al. (2011) conducted a case-control in Multiple Sclerosis (n=3,251). C-allele of SNP rs391745 near HERV-Fc1 vs. Non-carriers of the C-allele was evaluated on Association with multiple sclerosis (OR 1.54, 95% CI 1.27-1.87, p=1.3*10^-5). Carriage of the C-allele of SNP rs391745 near the human endogenous retrovirus HERV-Fc1 was significantly associated with an increased risk of multiple sclerosis (OR 1.54).
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