Key result
Virtual prototyping of carotid bifurcations identifies optimal reconstructions minimizing critical hemodynamic wall parameters.
Why the study?
Do specific geometric design options for surgical reconstruction of diseased carotid artery bifurcations minimize critical hemodynamic wall parameters?
Do specific geometric design options for surgical reconstruction of diseased carotid artery bifurcations minimize critical hemodynamic wall parameters?
Computational fluid dynamics simulations of carotid artery bifurcations identify optimal geometric designs for surgical reconstruction that minimize adverse hemodynamic wall parameters.
Does not support changing carotid reconstruction techniques; leaves open translation of optimized geometries to human outcomes.
Based on the hypothesis that aggravating hemodynamic factors play a key role in the onset of arterial diseases, the methodology of "virtual prototyping" of branching blood vessels was applied to diseased external carotid artery (ECA) segments. The goals were to understand the underlying particle-hemodynamics and to provide various geometric design options for improved surgical reconstruction based on the minimization of critical hemodynamic wall parameters (HWPs). First, a representative carotid artery bifurcation (CAB) and then CABs with stenosed ECAs, i.e., a distally occluded ECA and an ECA stump, were analyzed based on transient three-dimensional blood flow solutions, employing a user-enhanced commercial finite volume code. Specifically, the HWPs, i.e., oscillatory shear index, wall shear stress angle gradient, near-wall residence time of monocytes, and near-wall helicity angle difference were evaluated to compare the merits of each design option, including a reconstructed near-optimal junction which generates the lowest HWP-values. The results provide physical insight to the biofluid dynamics of branching blood vessels and guide vascular surgeons as well as stent manufacturers towards interventions leading to high sustained patency rates.
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Kleinstreuer et al. (2004) studied Diseased carotid artery bifurcations. Geometric design options for surgical reconstruction vs. Diseased external carotid artery segments (distally occluded and stump) was evaluated on Hemodynamic wall parameters (oscillatory shear index, wall shear stress angle gradient, near-wall residence time of monocytes, near-wall helicity angle difference). Virtual prototyping of carotid artery bifurcations identified a reconstructed near-optimal junction that generates the lowest critical hemodynamic wall parameter values compared to diseased segments.
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