Key result
COVID-19 infection linked to fatal ARDS and fulminant myopericarditis in a 51-year-old male.
Why the study?
The cellular and molecular mechanisms of SARS-CoV-2-induced myopericarditis remain poorly understood.
Case Report (n=1)
This case highlights the potential for severe cardiac complications, specifically fulminant myopericarditis, as a direct result of COVID-19 infection.
Warrants awareness of rare fatal myopericarditis in COVID-19; extends case reports but leaves incidence and causality open.
Myopericarditis remains a prominent infectious inflammatory disorder throughout a patient's lifetime. Moreover, viral pathogens have been proven to be the leading contributors to myopericarditis in the pediatric and adult populations. Despite the current comprehensive knowledge of myocardial injury in viral and post-viral myopericarditis, the cellular and molecular mechanisms of SARS-CoV-2-induced myopericarditis are poorly understood. This report presents a case of coronavirus (COVID-19) fulminant myopericarditis and acute respiratory distress syndrome (ARDS) in a middle-aged male patient: a 51-year-old man with a history of hypertension who arrived to the emergency department with a dry cough, fatigue, dyspnea, and a fever. A real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay confirmed a diagnosis of COVID-19 infection, resulting in the patient's admission to the airborne isolation unit for clinical observation. When his condition began to deteriorate, the patient was transferred to the cardiac care unit after electrocardiography detected cardiac injury, demonstrating diffuse ST-segment elevation. Laboratory evaluations revealed elevated troponin T and BNP, with an echocardiogram indicating global left ventricular hypokinesia and a reduced ejection fraction. The patient was treated with hydroxychloroquine, azithromycin, dobutamine, remdesivir, and ventilatory support. This specific case highlights the severity and complications that may arise as a direct result of COVID-19 infection.
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Hussain et al. (2020) conducted a case report in COVID-19, Fulminant Myopericarditis, Acute Respiratory Distress Syndrome (ARDS) (n=1). COVID-19 infection was evaluated on Clinical course and mortality. COVID-19 infection in a 51-year-old male led to severe complications including acute respiratory distress syndrome and fulminant myopericarditis, ultimately resulting in death.
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