A straightforward method for the asymmetric fluorination of 4‐substituted isoxazolinones catalyzed by a bis‐cinchona alkaloid catalyst was developed. A series of 4‐fluoroisoxazolinone derivatives with a fluorine‐containing quaternary stereocenter were obtained in good to high yields with good enantioselectivities (up to 91 % yield, 85 % ee).
No takes yet. Share an insight, caveat, or question.
Zhang et al. (2015) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: