What is the clinical evidence from this study?

Study design: Cohort. Population: Post-myocardial infarction (n=1483). Intervention: Beta-blockers vs. No beta-blockers. Primary outcome: Incidence of cardiac events (recurrent MI, sudden death, and death by congestive heart failure) (OR 0.46, 95% CI 0.28-0.75, p=<0.01).

What does this research mean for the field?

Beta-blockers significantly reduce the incidence of cardiac events in post-myocardial infarction patients. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

January 1, 2000Japanese Heart JournalOpen Access

.BETA.-blockers Reduce the Incidence of Cardiac Events in Post-myocardial Infarction Patients.

Q: What are the key findings of this study?

Beta-blockers significantly reduced the incidence of cardiac events in post-myocardial infarction patients compared to no beta-blocker therapy (OR 0.46).

Q: What does this research mean for the field?

Beta-blockers significantly reduce the incidence of cardiac events in post-myocardial infarction patients. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

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Key result

Beta-blockers linked to ~54% fewer cardiac events in post-MI patients.

OR 0.46
95% CI 0.28-0.75
P<0.01
n=1,483

Why the study?

Does beta-blocker therapy reduce the incidence of cardiac events in post-myocardial infarction patients?

Population

1,483 post-myocardial infarction (MI) patients (Japanese cohort)

Comparison

Beta-blocker included in therapeutic regimen vs Therapeutic regimen without beta-blocker

Design

Cohort

Follow-up

17.4 +/- 20.9 months

Authors

IKIshikawa Kinji MMMiyataka Masaru KKKen KanamasaCedars-Sinai Medical Center

Discussion

Member takes

Implication

Supports beta-blocker consideration post-MI; hypothesis-generating in Japanese cohort and requires randomized confirmation.

Study Design

Type

Cohort (n=1,483)

Multicenter

Structured PICO

Does beta-blocker therapy reduce the incidence of cardiac events in post-myocardial infarction patients?

Population

1,483 post-myocardial infarction patients (mean age 60.1 years, 21.5% female) followed retrospectively for a mean of 17.4 months to evaluate the incidence of cardiac events.

Exposure

Beta-blocker included in therapeutic regimen

Comparator

Therapeutic regimen without beta-blocker

Outcome

Composite of cardiac events (recurrent MI, sudden death, and death by congestive heart failure)composite

Main Result

Odds Ratio: 0.46 (95% CI 0.28–0.75)

Absolute Event Rate: 3.2% vs 6.8%

p-value: p=<0.01

Beta-blocker therapy is associated with a significant reduction in recurrent MI, sudden death, and heart failure death in Japanese post-myocardial infarction patients.

Limitations

Retrospective study design
Significant differences in baseline medical backgrounds between the beta-blocker and control groups
Single-center study, lacking the rigor of a large, multicenter, placebo-controlled, randomized clinical trial
Retrospective design
Requires confirmation in a large, multicenter, placebo-controlled, randomized clinical trial

Cite This Study

Kinji et al. (2000) conducted a cohort in Post-myocardial infarction (n=1,483). Beta-blockers vs. No beta-blockers was evaluated on Incidence of cardiac events (recurrent MI, sudden death, and death by congestive heart failure) (OR 0.46, 95% CI 0.28-0.75, p=<0.01). Beta-blockers significantly reduced the incidence of cardiac events in post-myocardial infarction patients compared to no beta-blocker therapy (OR 0.46).

synapsesocial.com/papers/6aa6a0c489092379003a73d7 https://doi.org/10.1536/jhj.41.279

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January 1, 2000Japanese Heart JournalOpen Access

.BETA.-blockers Reduce the Incidence of Cardiac Events in Post-myocardial Infarction Patients.

View Full Paper

Ask AI

Bookmark

Key result

Beta-blockers linked to ~54% fewer cardiac events in post-MI patients.

OR 0.46
95% CI 0.28-0.75
P<0.01
n=1,483

Why the study?

Does beta-blocker therapy reduce the incidence of cardiac events in post-myocardial infarction patients?

Population

1,483 post-myocardial infarction (MI) patients (Japanese cohort)

Comparison

Beta-blocker included in therapeutic regimen vs Therapeutic regimen without beta-blocker

Design

Cohort

Follow-up

17.4 +/- 20.9 months

Authors

IKIshikawa Kinji MMMiyataka Masaru KKKen KanamasaCedars-Sinai Medical Center

Discussion

Member takes

Implication

Supports beta-blocker consideration post-MI; hypothesis-generating in Japanese cohort and requires randomized confirmation.

Study Design

Type

Cohort (n=1,483)

Multicenter

Structured PICO

Does beta-blocker therapy reduce the incidence of cardiac events in post-myocardial infarction patients?

Population

1,483 post-myocardial infarction patients (mean age 60.1 years, 21.5% female) followed retrospectively for a mean of 17.4 months to evaluate the incidence of cardiac events.

Exposure

Beta-blocker included in therapeutic regimen

Comparator

Therapeutic regimen without beta-blocker

Outcome

Composite of cardiac events (recurrent MI, sudden death, and death by congestive heart failure)composite

Main Result

Odds Ratio: 0.46 (95% CI 0.28–0.75)

Absolute Event Rate: 3.2% vs 6.8%

p-value: p=<0.01

Beta-blocker therapy is associated with a significant reduction in recurrent MI, sudden death, and heart failure death in Japanese post-myocardial infarction patients.

Limitations

Retrospective study design
Significant differences in baseline medical backgrounds between the beta-blocker and control groups
Single-center study, lacking the rigor of a large, multicenter, placebo-controlled, randomized clinical trial
Retrospective design
Requires confirmation in a large, multicenter, placebo-controlled, randomized clinical trial

Cite This Study

synapsesocial.com/papers/6aa6a0c489092379003a73d7 https://doi.org/10.1536/jhj.41.279

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

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