Key result
Regenerating Xenopus muscle shows persistent MyoD transcripts and transient myogenin expression in forming myotubes.
This study maps the spatial and temporal expression of myogenic regulatory factors during skeletal muscle regeneration in Xenopus laevis, identifying myogenin transcripts for the first time in this model.
Delineates MRF timing in amphibian regeneration; leaves open whether patterns extend to mammalian repair.
We have analyzed in adult Xenopus laevis, using in situ hybridization, the spatial and temporal expression patterns of MyoD, myogenin, and alpha-skeletal actin and fast myosin heavy chain mRNAs during muscle regeneration following cardiotoxin injury. MyoD transcripts could be detected in the satellite cells as early as the first stage of regeneration and were expressed persistently throughout the regeneration process. Myogenin mRNAs were transiently expressed in forming myotubes. alpha-Skeletal actin and fast myosin heavy chain mRNAs were detected precociously, before the young myotube stage. This work has shown, for the first time, the presence of myogenin transcripts during Xenopus myogenesis.
No takes yet. Share an insight, caveat, or question.
Nicolas et al. (1996) studied Muscle regeneration following cardiotoxin injury. Cardiotoxin injury was evaluated on Spatial and temporal expression patterns of MyoD, myogenin, and alpha-skeletal actin and fast myosin heavy chain mRNAs. In adult Xenopus laevis, MyoD transcripts were detected persistently throughout muscle regeneration, while myogenin mRNAs were transiently expressed in forming myotubes.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: