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December 1, 1998Journal of HepatologyOpen Access

Impact of hepatitis G virus co-infection on the course of hepatitis C virus infection before and after liver transplantation

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Authors

TBT BizollonSGSandra GuichardSASi Nafa Si Ahmed

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Overview

Cohort study observes that hepatitis G co-infection does not worsen hepatitis C recurrence or graft survival after liver transplantation, indicating hepatitis G has minimal clinical impact.

Key Points

  • To evaluate the prevalence of hepatitis G virus (HGV) infection and investigate whether HGV co-infection alters the clinical and histological course of hepatitis C virus (HCV) following liver transplantation.
  • Evaluated 89 liver transplant recipients with persistent HCV viremia, testing pre- and post-transplant serum for HGV RNA via two PCR assays and pre-transplant anti-E2 antibodies via EIA.
  • Followed recipients for a mean of 34 months (range: 6–70 months), evaluating an average of nine liver biopsy specimens per patient to measure recurrent graft hepatitis and disease severity.
  • HGV infection prevalence was 11% pre-transplantation and 19% post-transplantation (p<0.001 for correlation), while pre-transplant anti-E2 antibodies (34% seroprevalence) protected against post-transplant HGV infection (0/7 newly infected vs 40% uninfected, p=0.04).
  • Histological recurrence of hepatitis occurred in 75% (67/89) of patients at a mean of 12.2 months, with no significant differences in recurrence rate between co-infected and HCV-monoinfected groups (p=0.89).
  • Histological disease severity, graft survival, and overall patient survival did not differ between patients with HCV alone and those co-infected with HGV.

Cite This Study

Bizollon et al. (1998) studied this question.

synapsesocial.com/papers/6aa6a2f06a6f69d61978fcb6https://doi.org/10.1016/s0168-8278(98)80116-5
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