What is the clinical evidence from this study?

Study design: Observational. Population: Aseptic meningitis (n=417). Intervention: Coxsackie B5 and A9 virus infection. Primary outcome: Incidence and clinical features of aseptic meningitis.

What does this research mean for the field?

The 1961 Aomori outbreak of aseptic meningitis was primarily caused by Coxsackie B5 and to a lesser extent Coxsackie A9 viruses, with elevated amylase levels indicating pancreatic involvement in 30.9% of B5 and 23.0% of A9 cases. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Characterize the clinical and epidemiological patterns of an aseptic meningitis epidemic caused by Coxsackie B5 and A9 viruses.

January 1, 1964The Tohoku Journal of Experimental MedicineOpen Access

Clinical and Epidemiological Studies on an Outbreak of Aseptic Meningitis Caused by Coxsackie B5 and A9 Viruses in Aomori in 1961

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Key result

Coxsackie B5 virus linked to pediatric aseptic meningitis outbreak, with elevated amylase in ~31% of cases.

n=417

Population

417 patients with aseptic meningitis during a 1961 outbreak in Aomori City and adjacent rural communities…

Design

Cohort

Authors

TNTooru NakaoSapporo Medical University TNToshio NittaAomori Prefectural Central Hospital RMRyoichi MiuraHiroshima University

Discussion

Member takes

Implication

Historical outbreak data should not guide current practice; leaves open modern etiologic patterns and pancreatic involvement in pediatric meningitis.

Key Points

Characterize the clinical and epidemiological patterns of an aseptic meningitis epidemic caused by Coxsackie B5 and A9 viruses.
Clinical and epidemiological evaluation of N=417 patients presenting with aseptic meningitis during a seasonal epidemic.
Comparative analysis of clinical symptoms and laboratory measurement of serum and urinary amylase levels between Coxsackie B5 and A9 infections.
Peak incidence occurred in July and August, disproportionately affecting children under 10 years of age, with morbidity exceeding 500 per 100,000 in individuals under 15 years.
Clinical manifestations were largely indistinguishable between Coxsackie B5 and A9, although abdominal pain was more predominant in B5 cases.
Serum and/or urine amylase levels were elevated in 30.9% of Coxsackie B5 infections and 23.0% of Coxsackie A9 infections, signaling frequent pancreatic involvement.

Study Design

Type

Observational (n=417)

Structured PICO

Population

417 children and infants aged 15 years and under who presented with aseptic meningitis during a 1961 outbreak in Aomori, Japan.

Outcome

Clinical and epidemiological features of the aseptic meningitis outbreak

The study details a 1961 outbreak of aseptic meningitis caused by Coxsackie B5 and A9 viruses in Japan, highlighting a high incidence in children and frequent pancreatic involvement.

Limitations

The shortening of duration of pyrexia may have been influenced by lumbar puncture performed in all cases.
Autopsy was not performed on the single fatal case, leaving its exact viral etiology uncertain.

Cite This Study

Nakao et al. (1964) conducted an observational in Aseptic meningitis (n=417). Coxsackie B5 and A9 virus infection was evaluated on Incidence and clinical features of aseptic meningitis. An outbreak of aseptic meningitis in Aomori in 1961 affecting 417 children was predominantly caused by Coxsackie B5 virus, with elevated amylase levels observed in 30.9% of B5 cases.

synapsesocial.com/papers/6aa6a9b6d3d41ccc68923781 https://doi.org/10.1620/tjem.83.94

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Implication

Historical outbreak data should not guide current practice; leaves open modern etiologic patterns and pancreatic involvement in pediatric meningitis.

Clinical and Epidemiological Studies on an Outbreak of Aseptic Meningitis Caused by Coxsackie B5 and A9 Viruses in Aomori in 1961

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Limitations

Cite This Study

Clinical and Epidemiological Studies on an Outbreak of Aseptic Meningitis Caused by Coxsackie B5 and A9 Viruses in Aomori in 1961

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Limitations

Cite This Study

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Also Consider