Answers are grounded in this paper and cite their sources.
In this review, a comparison between the Lewis acid catalysed and organocatalysed 1,3-dipolar cycloaddition is presented with special focus on the enantioselective synthesis of five-membered hetero- or carbocyclic systems, is described. These reactions exhibit very interesting features, but the most important one is the generation of up to four stereogenic centres in only one reaction step.
No takes yet. Share an insight, caveat, or question.
Nájera et al. (2010) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: