Key result
Postoperative cTnI above procedure-specific thresholds linked to ~462% higher risk of death.
Why the study?
Although cardiac troponin is measured routinely after cardiac surgery for risk stratification, data are lacking on how elevated levels could change patient management.
Does postoperative cardiac troponin I elevation above specific thresholds predict 1-year cardiac mortality in adult patients undergoing cardiac surgery?
Observational (n=3,228)
No
Does postoperative cardiac troponin I elevation above specific thresholds predict 1-year cardiac mortality in adult patients undergoing cardiac surgery?
Odds Ratio: 5.62 (95% CI 3.37–9.37)
p-value: p=< 0.001
Postoperative cTnI concentrations above specific thresholds (4.2 µg/L for CABG, 10.7 µg/L for non-CABG) strongly predict 1-year cardiac mortality and may help identify patients who could benefit from targeted interventions.
May aid postoperative risk stratification after cardiac surgery; hypothesis-generating for targeted intervention trials.
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Provenchère et al. (2019) conducted an observational in Cardiac surgery (n=3,228). Postoperative cardiac troponin I > threshold vs. Postoperative cardiac troponin I ≤ threshold was evaluated on Death (OR 5.62, 95% CI 3.37-9.37, p=< 0.001). Postoperative cardiac troponin I concentrations above procedure-specific thresholds were associated with a significantly increased risk of death (OR 5.62; 95% CI 3.37-9.37; p < 0.001).
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