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July 26, 2023Molecular Biology and EvolutionOpen Access

On the Decoupling of Evolutionary Changes in mRNA and Protein Levels

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Authors

DJDaohan JiangACAlexander L. CopeJZJianzhi Zhang

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Overview

Theoretical modeling reveals compensatory evolution decouples mRNA and protein levels across lineages, explaining widespread mismatches between transcriptomic and proteomic data.

Key Points

  • To identify the evolutionary mechanisms and selective conditions that decouple mRNA abundance from protein levels across evolutionary lineages.
  • Constructed a theoretical coevolutionary model tracking the joint dynamics of mRNA levels and translation rates over time.
  • Simulated evolutionary outcomes across varying regulatory pathways under regimes of stabilizing and directional selection.
  • Stabilizing selection targeting protein levels consistently drives widespread compensatory evolution between mRNA abundance and translational regulation across multiple regulatory pathways.
  • Under directional selection, mRNA levels and translation rates for the same gene correlate negatively across lineages but correlate positively across different genes.

Cite This Study

Jiang et al. (2023) studied this question.

synapsesocial.com/papers/6aa6b2c84dd50f8a0764ca15https://doi.org/10.1093/molbev/msad169
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