Key result
Software prototype unrolls 3D+t mitral valve segmentations into 2D to extract pathophysiological parameters.
Why the study?
Interpreting time-resolved 3D+t mitral valve segmentations can be ambiguous because of complex valve surfaces and multiple time steps across the cardiac cycle.
A novel software prototype for flattening 3D+t mitral valve segmentations into 2D representations may aid clinicians in diagnosing and evaluating reconstructive surgeries.
Answers are grounded in this paper and cite their sources.
May aid mitral valve parameter extraction in research; leaves open clinical validation before practice adoption.
The mitral valve, one of the four valves in the human heart, controls the bloodflow between the left atrium and ventricle and may suffer from various pathologies. Malfunctioning valves can be treated by reconstructive surgeries, which have to be carefully planned and evaluated. While current research focuses on the modeling and segmentation of the valve, we base our work on existing segmentations of patient-specific mitral valves, that are also time-resolved ( 3D+t) over the cardiac cycle. The interpretation of the data can be ambiguous, due to the complex surface of the valve and multiple time steps. We therefore propose a software prototype to analyze such 3D+t data, by extracting pathophysiological parameters and presenting them via dimensionally reduced visualizations. For this, we rely on an existing algorithm to unroll the convoluted valve surface towards a flattened 2D representation. In this paper, we show that the 3D+t data can be transferred to 3D or 2D representations in a way that allows the domain expert to faithfully grasp important aspects of the cardiac cycle. In this course, we not only consider common pathophysiological parameters, but also introduce new observations that are derived from landmarks within the segmentation model. Our analysis techniques were developed in collaboration with domain experts and a survey showed that the insights have the potential to support mitral valve diagnosis and the comparison of the pre- and post-operative condition of a patient.
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Eulzer et al. (2019) studied Mitral valve pathology. Software prototype for 3D+t data analysis and 2D unrolling was evaluated on Extraction of pathophysiological parameters and dimensionally reduced visualizations. A proposed software prototype successfully unrolls 3D+t patient-specific mitral valve segmentations into 2D representations, allowing domain experts to extract pathophysiological parameters.
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