Key result
DCM with FMR exhibits ~17-fold larger mitral tenting volumes and reduced annular height versus controls.
Why the study?
Can a novel anatomical image creation system using real-time 3D echocardiography quantify geometric differences in the mitral apparatus between normal subjects and patients with functional mitral regurgitation?
Cross-Sectional (n=12)
No
Can a novel anatomical image creation system using real-time 3D echocardiography quantify geometric differences in the mitral apparatus between normal subjects and patients with functional mitral regurgitation?
Absolute Event Rate: 5.02% vs 0.29%
p-value: p=<0.001
A novel 3D echocardiography software system successfully quantifies geometric alterations of the mitral apparatus, demonstrating significant annular flattening and leaflet tenting in patients with functional mitral regurgitation.
Novel 3D echo quantifies mitral tenting and flattening in functional MR; leaves open prognostic or therapeutic utility.
Background. Three-dimensional (3D) echocardiography is an ideal tool for the assessment of morphology and function of the cardiovascular system including the geometry of the mitral apparatus. However, quantitative assessment of deformity of the mitral apparatus has been performed on a two-dimensional plane obtained from the 3D dataset, in spite of its unique configuration. We developed a novel software, which allowed us 3D visualization and quantitative analysis of the geometry of mitral leaflets and annulus by using transthoracic real-time 3D echocardiography.Methods. We examined 6 normal subjects and 6 patients with dilated cardiomyopathy with functional mitral regurgitation (DCM-MR) by using this system.Results. We succeeded in all study subjects to demonstrate the mitral leaflets and annulus in the 3D geometrical view. Furthermore, we could measure curved annular circumference, curved annular surface area, annular height, and the mitral leaflets tenting volume from the 3D data.Conclusions. 3D geometry of the mitral leaflets and annulus were clearly demonstrated and quantified by our novel anatomical image creation system by using transthoracic real-time 3D echocardiography. This technique may be applicable to 3D quantitative analysis of the mitral apparatus for decision making in surgical strategy in each patient with mitral valve disease and may be useful in further investigations regarding the mechanism of functional mitral regurgitation.
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Yamaura et al. (2004) conducted a cross-sectional in Dilated cardiomyopathy with functional mitral regurgitation (n=12). Dilated cardiomyopathy with functional mitral regurgitation vs. Normal subjects was evaluated on Mitral leaflet tenting volume (ml) (p=<0.001). Patients with dilated cardiomyopathy and functional mitral regurgitation had significantly larger mitral leaflet tenting volumes (5.02 vs 0.29 ml, p<0.001) and reduced annular height compared to normal subjects.
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