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Endothelin-1 (ET-1), a unique vasoconstrictor peptide, may play a role as a physiologic or pathologic mediator.The potent and sustained actions of exogenously administered ET-1 on smooth muscle raise the question of how these actions may be modulated when the peptide is released endogenously.We report here that vasoactive intestinal peptide (VIP), a widely distributed neuropeptide, can reverse the constrictor effect of ET-1 on guinea-pig tracheal smooth muscle segments and reduce ET-induced contractions of guinea-pig pulmonary artery segments.VIP may thusbe one of the endogenous modulators of the actions of ET-1.
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Boomsma et al. (1991) studied this question.
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