Key result
Continuous IV hydrocortisone achieves target cortisol at lower daily doses than intermittent injections in acute asthma.
Why the study?
Do different regimens of corticosteroids effectively improve clinical and biochemical indices in patients with severe acute asthma?
Population
23 patients admitted to hospital with severe acute asthma
Comparison
Tetracosactrin depot or intravenous… vs Different corticosteroid regimens
Design
Cohort
Authors
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May support continuous hydrocortisone infusion for efficient cortisol targeting in severe asthma; leaves open clinical outcome differences versus intermittent dosing.
Do different regimens of corticosteroids effectively improve clinical and biochemical indices in patients with severe acute asthma?
Continuous intravenous infusion of hydrocortisone is more efficient than intermittent injections for maintaining high plasma cortisol levels in severe acute asthma, with clinical improvement typically beginning within 4 to 6 hours.
Collins et al. (1975) studied severe acute asthma (n=23). Corticosteroids (tetracosactrin depot and intravenous hydrocortisone) vs. Intermittent injections was evaluated on Plasma cortisol levels, FEV1, FVC, and pulse rate. Continuous intravenous infusion of hydrocortisone required a lower total daily dose to achieve plasma cortisol levels >100 mug/100 ml compared with intermittent injections in severe acute asthma.
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