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October 17, 2013PLoS ONEOpen Access

In patients with nonvalvular atrial fibrillation, a CHA2DS2-VASc score of 1 was associated with significantly greater left atrial remodeling, including increased maximum left atrial volume index (40.27 vs 26.79, p=0.002), compared to a score of 0.

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Population

100 patients with atrial fibrillation

Design

Cross-sectional

Key result

In patients with nonvalvular atrial fibrillation, a CHA2DS2-VASc score of 1 was associated with significantly greater left atrial remodeling, including increased maximum left atrial volume index (40.27 vs 26.79, p=0.002), compared to a score of 0.

Authors

YLYihui LiWDWen‐Yuan DingHWHua Wang

Discussion

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Overview

May warrant caution in low-risk AF anticoagulation decisions; leaves open whether CHA2DS2-VASc better identifies remodeling than CHADS2.

Study Design

Type

Cross-Sectional (n=100)

Multicenter

No

Structured PICO

P
Population
100 consecutive patients with nonvalvular atrial fibrillation, free of valve or primary myocardial disease, evaluated cross-sectionally for left atrial remodeling.
O
Outcome
Left atrial remodeling status assessed quantificationally by echocardiography (maximum LA volume index, LA total emptying fraction, and LA mean strain)surrogate

Main Result

Absolute Event Rate: 40.27% vs 26.79%

p-value: p=0.002

The CHA2DS2-VASc score is better than the CHADS2 score at identifying left atrial remodeling in atrial fibrillation patients presenting with low stroke risk.

Limitations

  • Relatively small study population.
  • Variations in drug utilization, such as ARBs, may have resulted in data variability.
  • Duration from the last atrial fibrillation attack may affect atrial and ventricular function in paroxysmal AF patients.

Cite This Study

Li et al. (2013) conducted a cross-sectional in Nonvalvular atrial fibrillation (n=100). CHA2DS2-VASc score of 1 vs. CHA2DS2-VASc score of 0 was evaluated on Maximum left atrial volume index (LAVImax) (p=0.002). In patients with nonvalvular atrial fibrillation, a CHA2DS2-VASc score of 1 was associated with significantly greater left atrial remodeling, including increased maximum left atrial volume index (40.27 vs 26.79, p=0.002), compared to a score of 0.

synapsesocial.com/papers/6aa6ba80bc2c7db7488e6ddfhttps://doi.org/10.1371/journal.pone.0077653
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Also Consider

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