Why the study?
Individual components of the CHA2DS2-VASc score may affect left atrial function, but whether left atrial function assessed by speckle-tracking echocardiography differs in sinus rhythm patients according to score was unknown.
Does a higher CHA2DS2-VASc score correlate with reduced left atrial function assessed by speckle-tracking echocardiography in patients with sinus rhythm?
Population
150 patients with sinus rhythm
Comparison
Low vs moderate vs high CHA2DS2-VASc score groups
Key result
High CHA2DS2-VASc scores in patients with sinus rhythm were associated with significantly lower left atrial reservoir strain (33.2 vs 40.6) and conduit strain (20.3 vs 26.9) than low scores (P<0.01).
Authors
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LA strain differences by CHA2DS2-VASc in sinus rhythm are hypothesis-generating; prospective validation needed before clinical use.
Cross-Sectional (n=150)
Does a higher CHA2DS2-VASc score correlate with reduced left atrial function assessed by speckle-tracking echocardiography in patients with sinus rhythm?
p-value: p=< 0.01
Higher CHA2DS2-VASc scores are associated with reduced left atrial reservoir and conduit strain in patients with sinus rhythm, largely mediated by left ventricular diastolic dysfunction.
Mahmoud et al. (2026) conducted a cross-sectional in Sinus rhythm (n=150). High CHA2DS2-VASc score vs. Low and moderate CHA2DS2-VASc score was evaluated on Left atrial reservoir strain (LASr) and LA conduit strain (LAScd) (p=< 0.01). High CHA2DS2-VASc scores in patients with sinus rhythm were associated with significantly lower left atrial reservoir strain (33.2 vs 40.6) and conduit strain (20.3 vs 26.9) than low scores (P<0.01).
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