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Hepatocyte ballooning in MASLD is a transcriptionally active, stepwise process characterized by a specific eight-gene signature, a lipotoxic point of no return, and pro-fibrogenic signaling that has prognostic relevance for hepatocellular carcinoma. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

Transcriptomic trajectory of hepatocyte ballooning reveals a lipotoxic point of no return and initiates oncogenic regulatory rewiring in MASLD

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