Key result
Cytochalasin B or D inhibits T. cruzi invasion of heart cells by ~75% via cytoskeleton disruption.
Population
Heart muscle cells (HMC) and Trypanosoma cruzi
Comparison
Pre-treatment of heart muscle cells with… vs Untreated normal heart muscle cells
Design
Preclinical
Follow-up
1 to 3 hours
Authors
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No immediate clinical implications for Chagas disease; leaves open cytoskeleton targeting as a research avenue in T. cruzi invasion.
The cytoskeleton of heart muscle cells actively participates in the internalization of Trypanosoma cruzi during infection.
Barbosa et al. (1995) studied Trypanosoma cruzi infection. Cytochalasin B and D vs. Untreated control (DMSO) was evaluated on Percentage of parasite internalization. Pre-treatment of heart muscle cells with cytochalasin B or D inhibited the uptake of Trypanosoma cruzi by approximately 65% and 75%, suggesting active involvement of host cytoskeleton elements during invasion.
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