Experimental optimization demonstrates improved yield in ethyl(2-phthalimidoethoxy)acetate synthesis, indicating successful byproduct suppression via factorial design.
We investigated the reaction of alkylation of 2-phthalimidoethanol with ethyl chloroacetate leading to ethyl(2-phthalimidoethoxy)acetate. The synthesis was successfully optimised by applying factorial design. Major side products have been separated, identified, and characterised. The yield level was increased from 25% to 52%, and a method of decreasing the amount of side products has been proposed.
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Synoradzki et al. (2004) studied this question.
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