Key result
IV thorium dioxide yields superior cardiovascular visualization in animals for ~2 hours.
Why the study?
Does intravenous thorium dioxide improve experimental angiography compared to conventional methods in animals?
Does intravenous thorium dioxide improve experimental angiography compared to conventional methods in animals?
Intravenous thorium dioxide provides a superior, prolonged, and constant visualisation of the cardiovascular system for experimental animal angiography compared to conventional methods.
Thorium dioxide enables prolonged animal angiography; leaves open any clinical translation pending safety data.
An improved method for experimental angiography is presented. It is based on a high concentration of contrast medium in the circulating blood giving a fairly constant visualisation of the cardiovascular system for some period of time. (1) One single dose of 5–10 ml/kg body weight of a solution of thorium dioxide (25% Thorotrast) given intravenously creates a blood concentration of contrast medium sufficient to visualise the heart, arteries, veins and the small branches for about 2 hours and for a longer time the liver, spleen and kidneys. (2) The blood concentration remains fairly constant from 30 minutes up to one hour as determined by densitometry and measurements of the radioactivity of thorium dioxide in blood samples taken at intervals after the injection of 10 ml/kg body weight in a cat. During this period the radiographs are in all probability strictly comparable. (3) The method presented is compared with the conventional one for angiography and found superior for experimental work on animals.
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Ekholm et al. (1964) studied Experimental angiography. Thorium dioxide (25% Thorotrast) vs. Conventional method for angiography was evaluated on Visualisation of the cardiovascular system. Intravenous administration of 5-10 ml/kg of thorium dioxide provided a constant blood concentration for up to two hours, allowing superior cardiovascular visualization in experimental animals.
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