Key result
Early infected pacemaker lead removal is linked to glomerulonephritis resolution and restored kidney function.
Why the study?
There is a scarcity of knowledge regarding glomerulonephritis resulting from cardiac pacemaker-lead infections, and current guidelines do not address it as an indication for lead removal.
Does early surgical removal of the cardiac pacemaker lead, in conjunction with antibiotics and steroids, resolve glomerulonephritis in patients with cardiac pacemaker-lead infections?
Case Report (n=1)
Does early surgical removal of the cardiac pacemaker lead, in conjunction with antibiotics and steroids, resolve glomerulonephritis in patients with cardiac pacemaker-lead infections?
Early surgical removal of an infected cardiac pacemaker lead, combined with antibiotics and steroids, can successfully resolve associated glomerulonephritis, suggesting a potential indication for lead extraction not currently addressed in guidelines.
Answers are grounded in this paper and cite their sources.
GN may complicate pacemaker lead infections; this Level 5 case leaves open prevalence, causality, and management implications.
The incidence of cardiac pacemaker lead infections is increasing due to the rise in cardiac implantable device use. These infections mimic infective endocarditis (IE) and cause a variety of complications. However, there is a scarcity of knowledge regarding glomerulonephritis (GN) resulting from cardiac pacemaker-lead infections. This report describes a 71-year-old female who presented with GN associated with a cardiac pacemaker-lead infection. The patient was successfully treated with intravenous (IV) antibiotics, IV steroids, and early surgical removal of the cardiac pacemaker lead, resulting in the resolution of GN. Current guidelines do not address cardiac pacemaker lead infection-associated GN as an indication for lead removal. Given the success of our treatment approach and the rising incidence of cardiac pacemaker infections, we suggest the consideration of early surgical removal of the cardiac lead, in conjunction with antibiotics and steroids, for the treatment of cardiac lead infection associated with GN. Further research is necessary to determine the prevalence and optimal management of this complication.
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Said et al. (2023) conducted a case report in Glomerulonephritis associated with cardiac pacemaker-lead infection (n=1). Surgical removal of cardiac pacemaker lead with antibiotics and steroids was evaluated on Resolution of glomerulonephritis and return of baseline kidney function. Early surgical removal of an infected cardiac pacemaker lead, combined with antibiotics and steroids, resulted in the resolution of glomerulonephritis and return to baseline kidney function.
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