The asymmetric synthesis of (–)-epibatidine 1, employing as the key step the asymmetric protonation of the achiral lithum enolate of cyclohexanone derivative 5 with chiral β-hydroxy sulfoxide 3b, is described.
No takes yet. Share an insight, caveat, or question.
Kosugi et al. (1997) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: