Key result
Mendelian randomization identifies six causal proteins for CAVD, highlighting ANGPTL4 and ITGAV as promising targets.
Why the study?
Calcific aortic valve disease has no available pharmacological treatments, and novel therapeutic targets are needed.
Which plasma proteins are causally associated with calcific aortic valve disease?
Observational (n=1,066,048)
Yes
Which plasma proteins are causally associated with calcific aortic valve disease?
Mendelian randomization identifies ANGPTL4 and ITGAV as promising novel therapeutic targets for calcific aortic valve disease.
May support preclinical validation of ANGPTL4 and ITGAV; leaves open therapeutic translation pending functional and trial data.
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Xu et al. (2025) conducted an observational in Calcific aortic valve disease (CAVD) (n=1,066,048). Plasma proteins was evaluated on Causal targets of CAVD. Mendelian randomization identified six causal proteins with strong genetic colocalization for calcific aortic valve disease, with ANGPTL4 and ITGAV emerging as the most promising targets.
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