Key result
High hsCRP linked to ~64% higher risk of death or transplant in idiopathic dilated cardiomyopathy.
Why the study?
Does elevated high-sensitivity C-reactive protein predict major arrhythmic events and transplant-free survival in patients with idiopathic dilated cardiomyopathy?
Cohort (n=198)
Does elevated high-sensitivity C-reactive protein predict major arrhythmic events and transplant-free survival in patients with idiopathic dilated cardiomyopathy?
In patients with idiopathic dilated cardiomyopathy, elevated hsCRP is an independent predictor of death or cardiac transplantation but does not predict major arrhythmic events.
May aid prognostication for transplant-free survival in idiopathic dilated cardiomyopathy; hypothesis-generating and should not yet change practice.
We analyzed the serum concentrations of high-sensitivity C-reactive protein (hsCRP) at the time of diagnostic cardiac catheterization in 198 patients with idiopathic dilated cardiomyopathy (IDC) to evaluate its prognostic value. Patients were dichotomized according to a median value of hsCRP of 2 mg/dL. Predefined study endpoints over 69 +/- 33 months of follow-up included major arrhythmic events and transplant-free survival. Major arrhythmic events during follow-up occurred in 20 of 98 patients (20%) with low, compared to 22 of 100 patients (22%) with high hsCRP (ns). By multivariate analysis, a depressed left ventricular ejection fraction (LVEF) was the only significant predictor of arrhythmic risk. Death or cardiac transplantation was observed in 36% of patients with high, versus 22% of patients with low hsCRP (P < 0.05). By multivariate analysis, hsCRP and LVEF were independent predictors of transplant-free survival. Thus, in this patient population with IDC, hsCRP had independent prognostic value with regard to transplant-free survival, but did not contribute in the stratification with regard to arrhythmic risk.
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Lamparter et al. (2005) conducted a cohort in idiopathic dilated cardiomyopathy (IDC) (n=198). High hsCRP (≥ 2 mg/dL) vs. Low hsCRP (< 2 mg/dL) was evaluated on Death or cardiac transplantation (p=< 0.05). High hsCRP (≥2 mg/dL) was associated with a higher rate of death or cardiac transplantation compared to low hsCRP (36% vs 22%, P<0.05) in patients with idiopathic dilated cardiomyopathy.
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