What question did this study set out to answer?

To explore the role of C-reactive protein (CRP) in predicting outcomes for patients with idiopathic dilated cardiomyopathy (DCM).

January 1, 1999Cardiology

C-Reactive Protein in Dilated Cardiomyopathy

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Idiopathic dilated cardiomyopathy (n=188). Intervention: C-reactive protein (CRP) measurement vs. Long-term survivors (≥5 years). Primary outcome: Mean CRP concentration (mg/dl) in patients dying within 5 years vs long-term survivors (p=<0.05).

View Full Paper

Ask AI

Bookmark

Key result

Elevated plasma C-reactive protein concentrations were significantly associated with death within 5 years in patients with idiopathic dilated cardiomyopathy (1.05 vs 0.49 mg/dl; p<0.05).

Why the study?

Does elevated C-reactive protein (CRP) predict 5-year mortality in patients with idiopathic dilated cardiomyopathy?

Key Points

To explore the role of C-reactive protein (CRP) in predicting outcomes for patients with idiopathic dilated cardiomyopathy (DCM).
Measured plasma concentrations of CRP in 188 patients over 5-8 years, all with DCM and left ventricular ejection fraction < 40%.
Divided patients into two groups: those dying within 5 years and long-term survivors with at least 5 years survival.
Conducted baseline assessments including echocardiography and electrocardiography.
Patients who died within 5 years had higher CRP levels (1.05 +/- 1.37 mg/dl) compared to survivors (0.49 +/- 1.04 mg/dl, p < 0.05).
62% of patients with CRP > 1.0 mg/dl died within 5 years.
Routine CRP measurements effectively identified high-risk patients requiring special treatment.

Study Design

Type

Cohort (n=188)

Structured PICO

Does elevated C-reactive protein (CRP) predict 5-year mortality in patients with idiopathic dilated cardiomyopathy?

Population

188 patients with idiopathic dilated cardiomyopathy (DCM), presenting with dyspnea and fatigue at rest, and left ventricular ejection fraction <40%

Intervention

Elevated plasma C-reactive protein (CRP) concentrations (e.g., >1.0 mg/dl)

Comparator

Lower plasma C-reactive protein (CRP) concentrations

Outcome

Death within 5 years following admissionhard clinical

Main Result

Absolute Event Rate: 1.05% vs 0.49%

p-value: p=<0.05

Elevated baseline C-reactive protein is a significant predictor of 5-year mortality in patients with idiopathic dilated cardiomyopathy, identifying high-risk individuals who may require specialized treatment.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Suggests baseline inflammation may identify high-risk idiopathic dilated cardiomyopathy patients requiring closer surveillance; leaves open whether.

Cite This Study

Kaneko et al. (1999) conducted a cohort in Idiopathic dilated cardiomyopathy (n=188). C-reactive protein (CRP) measurement vs. Long-term survivors (≥5 years) was evaluated on Mean CRP concentration (mg/dl) in patients dying within 5 years vs long-term survivors (p=<0.05). Elevated plasma C-reactive protein concentrations were significantly associated with death within 5 years in patients with idiopathic dilated cardiomyopathy (1.05 vs 0.49 mg/dl; p<0.05).

synapsesocial.com/papers/6a11d2cc81e48c4370dcece1 https://doi.org/10.1159/000006913

Topics

Echocardiography Myocarditis

View Full Paper

Ask AI

Bookmark

Implication

Suggests baseline inflammation may identify high-risk idiopathic dilated cardiomyopathy patients requiring closer surveillance; leaves open whether.

C-Reactive Protein in Dilated Cardiomyopathy

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Topics

C-Reactive Protein in Dilated Cardiomyopathy

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Keep reading

Topics

Keep reading