January 1, 2005Cardiology
C-Reactive Protein Predicts Death in Patients with Non-Ischemic Cardiomyopathy
Key result
High baseline C-reactive protein independently predicted mortality in patients with non-ischemic left ventricular dysfunction compared to low CRP (30% vs 15%; HR 2.0; P=0.037).
Why the study?
Does high baseline C-reactive protein predict mortality in patients with non-ischemic left ventricular dysfunction?
Population
203 patients with non-ischemic left ventricular dysfunction undergoing cardiac catheterization
Comparison
High baseline C-reactive protein concentration vs Low baseline C-reactive protein concentration
Design
Cohort
Follow-up
2.4 +/- 1.4 years
Authors
Discussion
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Implication
May refine risk stratification in non-ischemic LV dysfunction; hypothesis-generating pending prospective validation.
Study Design
Type
Cohort (n=203)
Structured PICO
Does high baseline C-reactive protein predict mortality in patients with non-ischemic left ventricular dysfunction?
P
Population
203 patients with non-ischemic left ventricular dysfunction undergoing cardiac catheterization, followed for a mean of 2.4 years.
E
Exposure
High baseline C-reactive protein (CRP) concentration (3rd tertile)
C
Comparator
Low baseline C-reactive protein (CRP) concentration (1st and 2nd tertiles)
O
Outcome
Incidence of fatal events (death) at 2.4 +/- 1.4 years follow-uphard clinical
Main Result
Hazard Ratio: 2
Absolute Event Rate: 30% vs 15%
p-value: p=0.037
Elevated baseline CRP levels independently predict increased mortality in patients with non-ischemic left ventricular dysfunction.
Cite This Study
Ronnow et al. (2005) conducted a cohort in Non-ischemic cardiomyopathy (n=203). High C-reactive protein (3rd tertile) vs. Low C-reactive protein (1st and 2nd tertiles) was evaluated on Death (HR 2.0, p=0.037). High baseline C-reactive protein independently predicted mortality in patients with non-ischemic left ventricular dysfunction compared to low CRP (30% vs 15%; HR 2.0; P=0.037).