Key result
A systematic review of 24 reports found that standard 3% peroxide use lacks evidence, whereas diluted concentrations may retain bacterial decolonization benefits without increasing complication risks.
Why the study?
What is the evidence for the efficacy and safety of peroxide use in orthopedic surgery?
Systematic Review (n=24)
What is the evidence for the efficacy and safety of peroxide use in orthopedic surgery?
Diluted concentrations of peroxide may be preferable to standard 3% solutions in orthopedic surgery to balance bacterial decolonization with complication risks.
Challenges routine 3% peroxide use in orthopedics for lack of evidence; supports trials of diluted concentrations to retain decolonization benefits safely.
Peroxide is a strong oxidizing agent and disinfectant frequently used in orthopedic surgery. The authors conducted a systematic literature review of peroxide in orthopedic surgery, evaluating use, complications, efficacy, and appropriate concentrations. One hundred seventy-five reports were identified, with 24 being eligible for analysis. Orthopedic surgeons used peroxide for irrigation and bacterial reduction in various procedures. Complications included cytotoxicity, allergic reactions, suture damage, and inflammation. Use of the standard concentration of 3% peroxide and standard time in situ are without evidence. Laboratory studies suggest that diluted concentrations retain the benefit of bacterial decolonization without increasing the risk for complications. [Orthopedics. 2018; 41(6):e756-e764.].
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Navarro et al. (2018) conducted a systematic review in Orthopedic surgery (n=24). Peroxide was evaluated on Efficacy and complications. A systematic review of 24 reports found that standard 3% peroxide use lacks evidence, whereas diluted concentrations may retain bacterial decolonization benefits without increasing complication risks.
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