What is the clinical evidence from this study?

Study design: Other. Population: Ischemia and hypoxia. Intervention: Transglutaminase 2 (TG2). Primary outcome: Oxygen and glucose deprivation (OGD)-induced cell death and HIF-dependent transcription.

What does this research mean for the field?

Transglutaminase 2 protects neurons from oxygen and glucose deprivation-induced cell death by interacting with HIF1β and selectively attenuating HIF1-dependent transcriptional activation. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 28, 2008The FASEB JournalOpen Access

Transglutaminase 2 protects against ischemic insult, interacts with HIF1β, and attenuates HIF1 signaling

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Key result

TG2 protects neurons against oxygen and glucose deprivation-induced cell death and attenuates the HIF1 pathway.

Population

Neurons exposed to oxygen and glucose deprivation (OGD) and hypoxic conditions

Design

Preclinical

Authors

AFAnthony J. FilianoDuke University CBCraig D. C. BaileyUniversity of Guelph JTJanusz TucholskiGlycoScientific (United States)

Discussion

Member takes

Implication

TG2 modulation merits testing in mammalian stroke models; leaves open any role in clinical neuroprotection.

Structured PICO

Population

Neurons exposed to oxygen and glucose deprivation (OGD) and hypoxic conditions

Exposure

Increased Transglutaminase 2 (TG2) expression (including transaminase-inactive mutant C277S-TG2)

Outcome

Cell death, HIF-dependent transcription, and expression of Bnip3 and VEGFsurrogate

TG2 protects neurons against ischemic insult by interacting with HIF1beta and attenuating the HIF1 hypoxic response pathway, specifically downregulating proapoptotic Bnip3.

Cite This Study

Filiano et al. (2008) studied Ischemia and hypoxia. Transglutaminase 2 (TG2) was evaluated on Oxygen and glucose deprivation (OGD)-induced cell death and HIF-dependent transcription. Transglutaminase 2 (TG2) protects neurons against oxygen and glucose deprivation-induced cell death and attenuates the HIF1 hypoxic response pathway.

synapsesocial.com/papers/6aa6f869d4c94fa098d3b155 https://doi.org/10.1096/fj.07-097709

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Transglutaminase 2 protects against ischemic insult, interacts with HIF1β, and attenuates HIF1 signaling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Transglutaminase 2 protects against ischemic insult, interacts with HIF1β, and attenuates HIF1 signaling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider