Key result
Lower remnant cholesterol linked to higher long-term bleeding risk post-PCI.
Why the study?
To investigate the association between remnant cholesterol and low-density lipoprotein cholesterol concentrations and long-term bleeding.
Are lower remnant cholesterol and LDL cholesterol concentrations associated with long-term bleeding following percutaneous coronary intervention?
Cohort (n=10,724)
Are lower remnant cholesterol and LDL cholesterol concentrations associated with long-term bleeding following percutaneous coronary intervention?
Hazard Ratio: 0.47 (95% CI 0.26–0.85)
Lower remnant cholesterol, but not LDL cholesterol, is associated with an increased risk of long-term bleeding following PCI, highlighting the importance of RC in lipid management safety.
May signal higher bleeding risk with low remnant cholesterol post-PCI; leaves open causal role and requires prospective validation.
This study was aimed to investigate the association between remnant cholesterol (RC) and low-density lipoprotein cholesterol (LDL-C) concentrations and long-term bleeding. A total of 10,724 consecutive patients who underwent percutaneous coronary intervention in 2013 were prospectively enrolled. During a median follow-up of 5.1 years, 411 bleeding events and 42 intracranial hemorrhages (ICH) were recorded. The findings revealed that lower RC concentrations were independently associated with an increased risk of long-term bleeding events (continuous RC hazard ratio [HR]: 0.47, 95% confidence interval [CI]: 0.26–0.85; Q4 vs. Q1 HR: 0.66, 95% CI: 0.45–0.98), whereas lower LDL-C concentrations did not show a similar association. Additionally, a non-linear relationship was observed between RC concentrations and the risk of ICH ( P for non-linear trend = 0.014), but no such relationship was found for LDL-C concentrations. These results provided insights into the safety of LDL-C-lowering therapy and emphasized the significance of RC concentrations in lipid management.
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Li et al. (2023) conducted a cohort in percutaneous coronary intervention (n=10,724). Remnant cholesterol (RC) concentrations was evaluated on long-term bleeding events (HR 0.47, 95% CI 0.26-0.85). Lower remnant cholesterol concentrations were independently associated with an increased risk of long-term bleeding events following percutaneous coronary intervention (continuous HR 0.47; 95% CI 0.26-0.85).
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