We report 2 brothers with holoprosencephaly, endocrine dysgenesis, and micropenis. This combination has been reported once previously in sibs (2 sisters) by Hintz et al (1968). In that case, autosomal recessive inheritance may have been the cause. The same may be true in our patients, but X-linked recessive inheritance is not excluded.
No takes yet. Share an insight, caveat, or question.
Begleiter et al. (1980) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: