Key result
Epinephrine saline bone marrow flushing is linked to preventing BP and SPO2 drops during cement implantation.
Why the study?
Does flushing the bone marrow cavity with epinephrine hydrochloride saline prevent hemodynamic instability during bone cement implantation in elderly patients undergoing cemented hemiarthroplasty?
Cohort (n=128)
Does flushing the bone marrow cavity with epinephrine hydrochloride saline prevent hemodynamic instability during bone cement implantation in elderly patients undergoing cemented hemiarthroplasty?
p-value: p=<0.05
Flushing the bone marrow cavity with epinephrine hydrochloride saline during cemented hemiarthroplasty in elderly patients maintains hemodynamic stability.
Epinephrine saline flush may maintain stability during cement implantation in elderly hemiarthroplasty; hypothesis-generating and requires randomized confirmation.
This study was to investigate the influence of bone cement implantation on haemodynamics and the preventive effect of epinephrine hydrochloride on pulmonary embolism in elderly patients with cemented semihip replacement. 128 patients were retrospectively analyzed. The patients were treated with (group A, 64 cases) or without (group B, 64 cases) epinephrine hydrochloride saline. The monitoring indicators included systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), and pulse oxygen saturation (SPO2). The indicators of the two groups were compared before and 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10 minutes after bone cement implantation. Analysis of variance and SNK-q test were used for the statistical analysis. Blood pressure and SPO2 of group B decreased with statistical difference (P < 0.05) and HR increased without statistical significance, comparing with those of group A. In group A, SBP, DBP, MAP, HR, and SPO2 after bone cement implantation did not change significantly at each time point comparing with before implantation (P > 0.05). Bone cement implantation has significant influence on hemodynamics in elderly patients with hemiarthroplasty. Flushing the bone marrow cavity with saline epinephrine hydrochloride is an effective measure to reduce the incidence of bone cement pulmonary embolism.
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Qi et al. (2015) conducted a cohort in elderly patients with cemented semihip replacement (n=128). Epinephrine hydrochloride saline vs. Without epinephrine hydrochloride saline was evaluated on Haemodynamics (SBP, DBP, MAP, HR, and SPO2) (p=<0.05). Flushing the bone marrow cavity with saline epinephrine hydrochloride prevented significant decreases in blood pressure and SPO2 compared to control (P<0.05) during bone cement implantation.
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