What question did this study set out to answer?

To evaluate the humoral immune responses and neutralizing antibody activity elicited by different COVID-19 vaccine regimens, dosing intervals, and a third mRNA booster dose against the Delta and Omicron variants.

May 5, 2022Työväentutkimus VuosikirjaOpen Access

Comparative analysis of COVID-19 vaccine responses and third booster dose-induced neutralizing antibodies against Delta and Omicron variants

View Full Paper

Ask AI

Bookmark

Authors

MBMilja BelikUniversity of Turku PJPinja JalkanenUniversity of Turku RLRickard LundbergUniversity of Turku

Discussion

Member takes

Implication

Cohort study reveals extended dosing intervals and third mRNA booster doses enhance neutralizing antibodies in healthcare workers, suggesting broad cross-protection against Delta and Omicron.

Key Points

To evaluate the humoral immune responses and neutralizing antibody activity elicited by different COVID-19 vaccine regimens, dosing intervals, and a third mRNA booster dose against the Delta and Omicron variants.
Assessed serum antibody responses among healthcare workers (n = 328) receiving licensed COVID-19 vaccines.
Compared anti-SARS-CoV-2 spike and neutralizing antibodies across two-dose regimens of BNT162b2, mRNA-1273, or heterologous ChAdOx1/mRNA given at a 12-week interval versus BNT162b2 at a 3-week interval.
Measured cross-reactive neutralizing antibody titers against D614, Delta, and Omicron BA.1 variants following a third booster dose of BNT162b2 or mRNA-1273.
Two doses of BNT162b2, mRNA-1273, or ChAdOx1 combined with an mRNA vaccine spaced by 12 weeks induced equally high levels of anti-spike and neutralizing antibodies against D614 and Delta.
A short 3-week interval between BNT162b2 doses yielded 2- to 3-fold lower neutralizing antibody titers compared to the 12-week interval.
A third mRNA booster dose increased antibody titers 4-fold relative to post-second dose levels and elicited detectable neutralizing antibodies against the Omicron BA.1 variant.

Cite This Study

Belik et al. (2022) studied this question.

synapsesocial.com/papers/6aa703c1bb64cafef81b3557 https://doi.org/10.1038/s41467-022-30162-5

View Full Paper

Ask AI

Bookmark

Implication

Cohort study reveals extended dosing intervals and third mRNA booster doses enhance neutralizing antibodies in healthcare workers, suggesting broad cross-protection against Delta and Omicron.

Comparative analysis of COVID-19 vaccine responses and third booster dose-induced neutralizing antibodies against Delta and Omicron variants

Discussion

Member takes

Implication

Key Points

Cite This Study

Comparative analysis of COVID-19 vaccine responses and third booster dose-induced neutralizing antibodies against Delta and Omicron variants

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider