Key result
Natural product and drug interactions commonly affect drug metabolism via cytochrome P-450 isoenzymes and impairment of hepatic or renal function.
Physicians and pharmacists should be familiar with natural product-drug interactions to effectively counsel patients and manage drug therapy.
Natural product-drug interactions merit clinical vigilance in polypharmacy; leaves open cardiology-specific prevalence and outcome data.
The interaction of natural products and drugs is a common hidden problem encountered in clinical practice. The interactions between natural products and drugs are based on the same pharmacokinetic and pharmacodynamic principles as drug-drug interactions. Clinically important interactions appear to involve effects on drug metabolism via cytochrome P-450 isoenzymes, impairment of hepatic or renal function, and other possible mechanisms. To effectively counsel patients on interactions involving natural products, physicians, and pharmacists should be familiar with the most commonly used products, and have access to information on more obscure products. In this review, we describe details of drugs interaction with natural products and its impact on drug therapy management.
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Joshi et al. (2008) conducted a review in Natural product and drug interactions. Natural products was evaluated. Natural product and drug interactions commonly affect drug metabolism via cytochrome P-450 isoenzymes and impairment of hepatic or renal function.
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