Azasulfonamidopeptides as peptide bond hydrolysis transition state analogues. Part 1. Synthetic approaches

The title compounds, a novel class of peptide analogues in which an α-amino acid residue is replaced by a hydrazine-1, 2-diyl sulfonyl group -NHNRSO2-, are of potential interest as proteinase inhibitors. Synthetic approaches to such compounds and the X-ray molecular structures of two examples (16 and 28) are reported.