Plasma Cryoactivated Renin and Active Renin in Diabetes Mellitus*

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Diabetes mellitus. Intervention: Diabetes mellitus with and without nephropathy vs. Normal subjects. Primary outcome: Plasma renin activity (PRA) and inactive renin activated by cold (IR-C).

Q: What does this research mean for the field?

Patients with diabetes mellitus and nephropathy exhibit suppressed plasma renin activity, while cold-activated inactive renin increases following salt depletion and furosemide administration in diabetic patients but not in normal controls. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

M R Manchandia; Ved V. Gossain; Andrew M. Michelakis; D R Rovner

doi:10.1210/jcem-53-5-1025

November 1, 1981The Journal of Clinical Endocrinology & Metabolism

Plasma Cryoactivated Renin and Active Renin in Diabetes Mellitus*

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Why the study?

How do plasma renin activity and inactive renin respond to salt depletion and furosemide in normal subjects versus patients with diabetes mellitus?

Study Design

Type

Observational

Structured PICO

How do plasma renin activity and inactive renin respond to salt depletion and furosemide in normal subjects versus patients with diabetes mellitus?

P

Population

Normal subjects and patients with diabetes mellitus with and without nephropathy evaluated for plasma renin activity under varying salt diets and furosemide administration.

E

Exposure

Physiological maneuvers including normal salt diet, low salt diet, and furosemide administration.

C

Comparator

Normal subjects compared to patients with diabetes mellitus (with and without nephropathy).

O

Outcome

Levels of plasma renin activity (PRA), cold renin activity (CR), and inactive renin activated by cold (IR-C).surrogate

Patients with diabetes mellitus exhibit altered renin responses to salt depletion and furosemide, with suppressed plasma renin activity in the presence of nephropathy.

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Implication

Altered renin responses may complicate PRA interpretation in diabetic nephropathy; leaves open the utility of inactive renin profiling.

Abstract

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Cite This Study

Manchandia et al. (1981) conducted an observational in Diabetes mellitus. Diabetes mellitus with and without nephropathy vs. Normal subjects was evaluated on Plasma renin activity (PRA) and inactive renin activated by cold (IR-C).

synapsesocial.com/papers/6aa70c13eb8aab1a4ee08a9f https://doi.org/10.1210/jcem-53-5-1025

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Plasma Cryoactivated Renin and Active Renin in Diabetes Mellitus*

Study Design

Structured PICO

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Implication

Abstract

Discussion

Cite This Study

Plasma Cryoactivated Renin and Active Renin in Diabetes Mellitus*

Study Design

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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