Key result
Diabetes mellitus is linked to significantly higher plasma renin activity compared to normotensive controls.
Why the study?
The plasma renin activity in diabetic patients, including those with hypertension and diabetic complications, was not well characterized compared to matched control subjects.
Is plasma renin activity elevated in diabetic patients compared to non-diabetic controls?
Population
76 diabetic outpatients including 16 with untreated hypertension and 28 with diabetic complications
Comparison
Diabetic patients vs age- and sex-matched normotensive and hypertensive control subjects
Design
Case-control study
Authors
Loading...
May support renin assessment in diabetic hypertension; leaves open whether targeted inhibition alters outcomes.
Case-Control
Is plasma renin activity elevated in diabetic patients compared to non-diabetic controls?
p-value: p=<0.001
Plasma renin activity is significantly elevated in diabetic patients regardless of the presence of hypertension or diabetic complications, suggesting hypersecretion of renin.
Burden et al. (1979) conducted a case-control in Diabetes Mellitus. Diabetes Mellitus vs. Age- and sex-matched normotensive and hypertensive control subjects was evaluated on Plasma renin activity (PRA) (p=<0.001). Diabetes mellitus was associated with significantly higher plasma renin activity compared with age- and sex-matched normotensive control subjects (P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: