Key result
Type 1 diabetes is linked to RAAS suppression, marked by lower renin and higher ANP.
Why the study?
Poor glycaemic control and high blood pressure are important risk factors for retinopathy and nephropathy in Type 1 diabetes, and the role of RAAS in this process was investigated.
Are plasma renin activity, angiotensin II, and atrial natriuretic peptide levels altered in adults with Type 1 diabetes compared to healthy controls?
Case-Control (n=155)
Are plasma renin activity, angiotensin II, and atrial natriuretic peptide levels altered in adults with Type 1 diabetes compared to healthy controls?
Answers are grounded in this paper and cite their sources.
Adults with long-standing Type 1 diabetes exhibit RAAS suppression and elevated ANP levels, suggesting a state of fluid retention.
Poor glycaemic control and high blood pressure are two important risk factors for the development of retinopathy and nephropathy in Type 1 diabetes. The renin-angiotensin-aldosterone system (RAAS) may be involved in this process, since treatment with angiotensin-converting enzyme (ACE) inhibitors postpones the development of these complications. We investigated whether plasma renin activity (PRA), plasma angiotensin II (Ang II) and atrial natriuretic peptide (ANP) differed in Type 1 diabetic patients compared with healthy controls. We recruited 80 patients with Type 1 diabetes of more than 10 years' duration and 75 age-matched controls. We found that PRA and Ang II concentrations were significantly lower in patients than in the controls. The levels of ANP, on the other hand, were higher in patients than in controls. PRA correlated negatively to the mean value of HbA(1c) during the previous five years. PRA and Ang II were significantly lower in patients with mean HbA(1c) >8.4% compared with those with mean HbA(1c) <7.2%. In summary, we found patients with Type 1 diabetes to have RAAS suppression and increased ANP levels, suggesting a state of fluid retention.
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Bojestig et al. (2000) conducted a case-control in Type 1 diabetes (n=155). Type 1 diabetes vs. Healthy controls was evaluated on Plasma renin activity (PRA), plasma angiotensin II (Ang II) and atrial natriuretic peptide (ANP) levels. Patients with Type 1 diabetes had significantly lower plasma renin activity and angiotensin II concentrations, and higher ANP levels compared to healthy controls, suggesting RAAS suppression.
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