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October 1, 1974Diabetes

Decreased Response of Plasma Renin Activity to Orthostasis in Diabetic Patients with Orthostatie Hypotension

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Why the study?

Does upright posture elicit a different plasma renin activity response in diabetic patients with orthostatic hypotension compared to diabetic controls without orthostatic hypotension?

Population

16 diabetic patients maintained on a 100 mEq sodium diet, consisting of 8 patients with orthostatic…

Comparison

Upright posture for one-half hour and four hours. vs Diabetic matched controls without orthostatic…

Design

Case-control

Follow-up

4 hours

Authors

ACA.Richard ChristliebJoslin Diabetes CenterCMChoodappasetty MunichoodappaJoslin Diabetes CenterJBJan T. BraatenOttawa Hospital

Discussion

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Implication

Blunted renin response may contribute to orthostatic hypotension in diabetes; hypothesis-generating and requires prospective confirmation before clinical consideration.

Structured PICO

Does upright posture elicit a different plasma renin activity response in diabetic patients with orthostatic hypotension compared to diabetic controls without orthostatic hypotension?

P
Population
16 diabetic patients maintained on a 100 mEq sodium diet, consisting of 8 patients with orthostatic hypotension (OH) and 8 matched controls without OH.
I
Intervention
Upright posture for one-half hour and four hours.
C
Comparator
Diabetic matched controls without orthostatic hypotension undergoing the same postural changes.
O
Outcome
Plasma renin activity (PRA) response to upright posture.surrogate

Diabetic patients with orthostatic hypotension have a blunted plasma renin activity response to upright posture, suggesting an inadequate renin-angiotensin system response may contribute to their condition.

Cite This Study

Christlieb et al. (1974) studied this question.

synapsesocial.com/papers/6a6fbc9aa7fbea1e4407d59dhttps://doi.org/10.2337/diab.23.10.835
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Responses of Norepinephrine, Renin and Aldosterone to Standing in Diabetic Patients with Orthostatic Hypotension1982 · 2 citations
  2. 2Plasma Renin Activity and Hypertension in Diabetes Mellitus1976 · 149 citations
  3. 3Low plasma renin activity in normotensive patients with diabetes mellitus: relationship to neuropathy.1981 · 57 citations
  4. 4Hyporeninemic Hypoaldosteronism in Diabetes Mellitus: Studies of the Autonomic Nervous System's Control of Renin Release1979 · 78 citations
  5. 5Relative preservation of the renin‐angiotensin‐aldosterone system response to active orthostatism in type 2 diabetic patients with autonomic neuropathy and postural hypotension2003 · 5 citations