Key result
Diabetic patients with hyporeninemic hypoaldosteronism had significantly diminished renin responses to upright posture and no response to isoproterenol compared with controls.
Why the study?
Does autonomic nervous system dysfunction contribute to suppressed plasma renin activity in diabetic patients with hyporeninemic hypoaldosteronism?
Population
5 hyperkalemic, diabetic patients with mild to moderate renal insufficiency and evidence of autonomic or…
Comparison
Physiological maneuvers and infusion of the… vs Control subjects
Design
Case-control
Authors
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Autonomic dysfunction may contribute to hyporeninemic hypoaldosteronism in diabetes; hypothesis-generating and requires prospective confirmation.
Observational (n=5)
Does autonomic nervous system dysfunction contribute to suppressed plasma renin activity in diabetic patients with hyporeninemic hypoaldosteronism?
In diabetic patients with hyporeninemic hypoaldosteronism, altered sympathetic nervous system activity and a localized intrarenal defect at the beta-adrenergic receptor level may contribute to decreased plasma renin levels.
Tuck et al. (1979) conducted an observational in Hyporeninemic hypoaldosteronism in diabetes mellitus (n=5). Isoproterenol infusion and upright posture vs. Control subjects was evaluated on Renin response to upright posture and isoproterenol infusion. Diabetic patients with hyporeninemic hypoaldosteronism had significantly diminished renin responses to upright posture and no response to isoproterenol compared with controls.
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