Key result
Rivaroxaban is linked to no strokes and low bleeding in elderly, highly comorbid AF patients.
Why the study?
Does rivaroxaban therapy prevent thromboembolic events and maintain safety in elderly and highly comorbid patients with nonvalvular atrial fibrillation in routine practice?
Cohort
Yes
Does rivaroxaban therapy prevent thromboembolic events and maintain safety in elderly and highly comorbid patients with nonvalvular atrial fibrillation in routine practice?
In a real-world cohort of elderly, highly comorbid patients with nonvalvular atrial fibrillation, rivaroxaban was associated with no strokes and low rates of bleeding over a mean follow-up of 30.5 months.
Supports rivaroxaban in high-risk elderly NVAF; hypothesis-generating, requires randomized confirmation.
AIM: To analyze clinical profile and management of patients with nonvalvular atrial fibrillation treated with rivaroxaban in clinical practice according to age and to ascertain rates of thromboembolic and bleeding events during rivaroxaban therapy. METHODS: Retrospective study of nonvalvular atrial fibrillation patients that started rivaroxaban therapy between May 2013 and February 2017 in the cardiology department of two hospitals from Huesca, Spain. RESULTS: -VASc 3.5 ± 1.3; HAS-BLED 1.6 ± 0.7) were included. Comorbidity was common. After a mean duration of treatment of 30.5 ± 17.2 months, no strokes were reported. Rates of transient ischemic attack, major bleeding and intracranial bleeding were low. CONCLUSION: In this cohort of elderly and highly comorbid patients treated with rivaroxaban, rates of thromboembolic and bleeding events were low.
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Guinda et al. (2018) conducted a cohort in Nonvalvular atrial fibrillation. Rivaroxaban was evaluated on Thromboembolic and bleeding events. Rivaroxaban therapy in elderly, highly comorbid patients with nonvalvular atrial fibrillation resulted in no reported strokes and low rates of bleeding over a mean follow-up of 30.5 months.
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