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The base catalyzed reaction of 2‐aminoethanethiol (3) with trans‐3‐(p‐methoxyphenyl)glycidate (4) gave a mixture of isomeric lactams 5 and 6, and in addition, a by‐product 7. The structures of these isomers were proven by X‐ray crystallography. The data revealed that both isomers adopt the chair conformation in the solid state and the size of the heterocyclic ring in compound 5 is a six‐ and in compound 6 is a seven‐membered ring.
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Mohacsi et al. (1990) studied this question.
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